For horse's face, always apply as a wipe using a piece of clean, absorbent cloth, toweling (Turkish) or sponge. 10 Best Fly Spray for Horses. Lets talk about homemade fly spray for horses. In this article, you can find 5 horse fly repellents that are highly effective and long lasting. Espana Silks Natural Bug Spray works on you, horses of all ages (great for all animals) and is environmentally friendly! The reason why this heavy duty pest repellent and killer is on our list of best fly spray for horses is because it is a completely organic product and hence quite safe for use on your horses. Best Fly Spray for Horses. 4.4 out of 5 stars 527. 4.5 out of 5 stars 198. This fly repellent Horse Spray by Espree features herbal concentrates with botanical oils which provide a gentler and more soothing option to the range of horse spray in the market. Pyranha Wipe N’ Spray for Horses, Qt Pyranha Equine Spray & Wipe, Qt. >> Also read: Best Fly Spray For Dogs It contains horse coat conditioners, aloe vera which soothes irritated areas and sunscreen to help prevent sunburn. The Essentria IC3 is one of the best horse fly spray insecticide concentrate comes in a 1qt/946ml large Jar. The Absorbine Ultrashield EX brand Horse fly spray is one of the most potent fly repellents on the market. Specifications: